A COMPUTATIONALLY EFFICIENT ALGORITHM TO LEVERAGE AVERAGE INFORMATION REML FOR (CO)VARIANCE COMPONENT ESTIMATION IN THE GENOMIC ERA

A computationally efficient algorithm to leverage average information REML for (co)variance component estimation in the genomic era

Abstract Background Methods for estimating variance components (VC) using restricted maximum likelihood (REML) typically require elements from the inverse of the coefficient matrix of the mixed model slate vcc equations (MME).As genomic information becomes more prevalent, the coefficient matrix of the MME becomes denser, presenting a challenge for

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What Do We Do about Helicobacter pylori?

Heliobacter pylori and nonsteroidal anti-inflammatory drugs (NSAIDs) cause ulcers by different mechanisms.Under some circumstances, patients infected with H pylori may be less ultimate warrior hat prone to NSAID-associated ulcers than those who are H pylori-negative.Eradication trials have yielded differing results.However, those who have studied p

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